Anaplasma Phagocytophilum (HGE)

Kits: EliGene® Anaplasma Phagocytophilum UNI Kit (ref: 90061-UNI)
Package size:
50 reactions
Analytical specificity: Anaplasma Phagocytophilum
Specimens: urine, sputum, BAL, exudatesblood, urine, CSF, synovial fluid, tissue
Compatible instruments:
ABI 7000, ABI 7300, ABI 7500 (Applied Biosystems), LightCycler® 480 and LightCycler® Nano (ROCHE); fully compatible with RotorGene instruments; MyGo Mini, MyGo Pro (IT-IS Life Science)
CE certification: yes
Detection technology: Molecular Beacons
Clinical study description and results:
Within the frame of testing the functional characteristics of EliGene® Anaplasma phagocytophilum UNI kit overall 527 samples of ticks were analyzed. From these 527 ticks samples 26 samples were Anaplasma phagocytophilum positive. EliGene® Anaplasma phagocytophilum UNI kit diagnosed as Anaplasma phagocytophilum positive all 26 ticks samples. Totally 501 ticks samples were right determined by EliGene® Anaplasma phagocytophilum UNI kit as Anaplasma phagocytophilum negative. EliGene® Anaplasma phagocytophilum UNI kit shows 100% (527 from 527 samples) match in detection of Anaplasma phagocytophilum in comparison with results determined by method of Courtney JW et al. (2004).
Sensitivity: 100 %
Specificity: 100 %
Description:
Anaplasma phagocytophilum is obligate intracellular, gram-negative rickettsial organisms infecting human leukocytes. Anaplasma is transmitted to humans by tick bites (Ixodes scapularis, Ixodes ricinus and Ixodes pacificus). It causes human granulocytic anaplasmosis (HGA) previously known as human granulocytic ehrlichiosis (HGE). Typical symptoms include fever, headache, chills, and muscle aches and they usually occur within 1-2 weeks of a tick bite. The epidemiology of this infection is very much like that of Lyme disease (caused by Borrelia burgdorferi) and babesiosis (caused primarily by Babesia microti), which all have the same tick vector.
References:
Gary P. Wormser et al. 2006. The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 43 (9): 1089-1134.

Johan S. Bakken, MD, Stephen Dumler. 2008. Human Granulocytic Anaplasmosis. Clin Infect Dis. 22 (3): 433–448